Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.37 |
| ▸ | PDE6C | P51160 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | PDE8A | O60658 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895854 | 0.88 | PDE5A (0.45) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL14045386 | 0.86 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL14021159 | 0.86 | PDE5A (0.45) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL4901484 | 0.85 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL14021009 | 0.83 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL14021142 | 0.82 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL4905752 | 0.80 | PDE5A (0.41) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL4898303 | 0.80 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL14045384 | 0.80 | PDE5A (0.45) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL4901853 | 0.79 | PDE5A (0.40) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242661-A1 | Novel compounds useful for the treatment of degenerative & inflammatory diseases | GALAPAGOS NV (BE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242661-A1 | Novel compounds useful for the treatment of degenerative & inflammatory diseases | PDE4A, PDE7B, PDE4B | PDE5A 7/4885PDE1A 21/4885PDE1B 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.