Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | KLK3 | P07288 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178169 | 0.79 | MEN1 (0.47) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL4175832 | 0.75 | MEN1 (0.47) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL4179302 | 0.72 | MEN1 (0.52) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL27802881 | 0.70 | MEN1 (0.50) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL4178490 | 0.68 | KMT2A (0.52) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL14047511 | 0.68 | KMT2A (0.52) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL27781260 | 0.67 | MEN1 (0.36) | MEN1KMT2ACFTR | |
| SCHEMBL27802882 | 0.67 | KMT2A (0.50) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL27802844 | 0.65 | KMT2A (0.50) | MEN1KMT2ACFTRKLK3 | |
| SCHEMBL27781190 | 0.64 | MEN1 (0.36) | MEN1KMT2ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-B1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC (US) | 2016-01-27 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |