Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033609 | 0.91 | PDE2A (0.50) | PDE2AHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL4439670 | 0.88 | PDE2A (0.41) | PDE2ANPC1ALDH1A1PDPK1PRKCZ | |
| SCHEMBL4433594 | 0.87 | PDE2A (0.41) | PDE2ALMNAPDPK1PRKCZMARK2 | |
| SCHEMBL14033877 | 0.86 | PDE2A (0.40) | PDE2APDPK1PRKCZMARK2PDE10A | |
| SCHEMBL14033866 | 0.86 | PDE2A (0.45) | PDE2APDPK1PRKCZMARK2PDE10A | |
| SCHEMBL14033009 | 0.85 | PDE2A (0.44) | PDE2AHPGDHSD17B10PDPK1PRKCZ | |
| SCHEMBL14033013 | 0.82 | PDE2A (0.42) | PDE2AHPGDRAB9AALDH1A1LMNA | |
| SCHEMBL14033681 | 0.78 | PDE2A (0.39) | PDE2AALDH1A1HSD17B10PDPK1PRKCZ | |
| SCHEMBL14033688 | 0.73 | PDE2A (0.46) | PDE2AHPGDALDH1A1LMNAPDPK1 | |
| SCHEMBL4437980 | 0.72 | PDE2A (0.38) | PDE2AHPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008116898-A1 | PYRAZOLO [1,5-A]PYRIMIDINES AS INHIBITORS OF STEAROYL-COA DESATURASE | BIOVITRUM AB (PUBL) (SE) | 2008-10-02 | — | — | WO | disclosed |