SCHEMBL14049327

SCHEMBL14049327

CCc1ccc(CC2=CCCN2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.40
CYP2A6 P11509 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
HTR1D P28221 3/20 0.34
TAAR1 Q96RJ0 1/20 0.33
TP53 P04637 1/20 0.33
PLK1 P53350 1/20 0.32
LPL P06858 1/20 0.32
LIPG Q9Y5X9 1/20 0.32
ALDH1A1 P00352 1/20 0.31
IGF1R P08069 1/20 0.31
PIM1 P11309 1/20 0.31
PIM2 Q9P1W9 1/20 0.31
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
POLB P06746 1/20 0.31
CA2 P00918 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919240 0.77
SCHEMBL14252183 0.69
SCHEMBL2491352 0.68 TP53 (0.56) CYP2A6SMN1; SMN2TAAR1TP53PLK1
SCHEMBL36295 0.65 TP53 (0.67) CYP2A6SMN1; SMN2TAAR1TP53PLK1
Hydrogen Sulfide SCHEMBL29290777 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1
Hydrogen Sulfide SCHEMBL27925242 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1
Ammonia Solution, Strong SCHEMBL27293386 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1
SCHEMBL7542835 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1
SCHEMBL31498555 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1
SCHEMBL27756675 0.62 TP53 (0.62) CYP2A6SMN1; SMN2TAAR1TP53PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1980560-A2 C-glycoside derivatives for the treatment of diabetes Astellas Pharma Inc. (JP) 2008-10-15 EP disclosed