SCHEMBL14049337

SCHEMBL14049337

CCCCOCC1OC(c2cc(Cc3cc4ccccc4s3)ccc2F)[C@H](OCCCC)C(OCCCC)[C@@H]1OCCCC

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 12/20 0.55
SLC5A1 P13866 3/20 0.38
CHRM1 P11229 1/20 0.38
ADRA1A P35348 1/20 0.38
SLC6A3 Q01959 1/20 0.38
SSTR1 P30872 3/20 0.35
SSTR2 P30874 3/20 0.35
SSTR4 P31391 3/20 0.35
SSTR3 P32745 3/20 0.35
SSTR5 P35346 3/20 0.35
CHRNA7 P36544 1/20 0.33
ADRB2 P07550 1/20 0.33
CYP2A6 P11509 1/20 0.33
AGXT P21549 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12510096 1.00 SLC5A2 (0.55) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL12662625 0.90 SLC5A2 (0.44) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL14544802 0.89 SLC5A2 (0.55) SLC5A2SLC5A1SSTR1SSTR2SSTR4
SCHEMBL14545134 0.89 SLC5A2 (0.55) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL14544806 0.89 SLC5A2 (0.44) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL14544890 0.89 SLC5A2 (0.44) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL14545123 0.88 SLC5A2 (0.58) SLC5A2SLC5A1SSTR1SSTR2SSTR4
SCHEMBL12510056 0.88 SLC5A2 (0.43) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL17480492 0.88 SLC5A2 (0.43) SLC5A2SLC5A1CHRM1ADRA1ASLC6A3
SCHEMBL14544894 0.87 SLC5A2 (0.47) SLC5A2SSTR1SSTR2SSTR4SSTR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1980560-A2 C-glycoside derivatives for the treatment of diabetes Astellas Pharma Inc. (JP) 2008-10-15 EP disclosed