Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.76 |
| ▸ | GSK3B | P49841 | 10/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953218 | 0.87 | CDK2 (0.79) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12953207 | 0.87 | CDK2 (0.79) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12953328 | 0.86 | CDK2 (1.00) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13118479 | 0.84 | GSK3B (1.00) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12952873 | 0.84 | CDK2 (0.83) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12952856 | 0.82 | CDK2 (1.00) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12953002 | 0.82 | GSK3B (0.79) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12953158 | 0.82 | CDK2 (0.83) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13305408 | 0.81 | GSK3B (0.74) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13146191 | 0.81 | GSK3B (0.84) | CDK2GSK3BCCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |