Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 18/20 | 0.62 |
| ▸ | RPS6KA1 | Q15418 | 15/20 | 0.62 |
| ▸ | AKT2 | P31751 | 11/20 | 0.62 |
| ▸ | RPS6KA5 | O75582 | 8/20 | 0.62 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.61 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ULK1 | O75385 | 1/20 | 0.61 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | SMC2 | O95347 | 1/20 | 0.61 |
| ▸ | LATS1 | O95835 | 1/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
| ▸ | PRKCB | P05771 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536482 | 1.00 | AKT1 (0.62) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL13435150 | 0.89 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL3487654 | 0.89 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL3487959 | 0.89 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL14050892 | 0.88 | AKT1 (0.58) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL14050839 | 0.88 | AKT1 (0.79) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| Hydrochloric Acid SCHEMBL3487539 | 0.88 | AKT1 (0.79) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL13461478 | 0.87 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL13693040 | 0.87 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL12837971 | 0.86 | AKT1 (0.72) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121685-A1 | METHODS OF USE FOR INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |
| WO-2007058850-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |