Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545686 | 0.81 | KDM4E (0.57) | GSK3BMEN1KMT2AKDM4ECDK2 | |
| SCHEMBL3319549 | 0.81 | PDE10A (0.43) | GSK3BMEN1KMT2AKDM4ECDK2 | |
| SCHEMBL11931303 | 0.79 | CDK2 (0.56) | GSK3BMEN1KMT2AKDM4ECDK2 | |
| SCHEMBL19201116 | 0.79 | MEN1 (0.40) | GSK3BMEN1KMT2ACDK2CHEK1 | |
| SCHEMBL17192159 | 0.78 | GSK3B (0.39) | GSK3BMEN1KMT2AKDM4ECDK2 | |
| SCHEMBL12953777 | 0.78 | GSK3B (0.39) | GSK3BMEN1KMT2ACDK2CHEK1 | |
| SCHEMBL17192160 | 0.78 | GSK3B (0.39) | GSK3BMEN1KMT2ACDK2CHEK1 | |
| SCHEMBL14543039 | 0.78 | GSK3B (0.61) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL14050922 | 0.77 | CDK2 (0.51) | GSK3BMEN1KMT2AKDM4ECDK2 | |
| SCHEMBL14043374 | 0.76 | GSK3B (0.50) | GSK3BMEN1KMT2AKDM4ECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |