Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.70 |
| ▸ | KIT | P10721 | 10/20 | 0.70 |
| ▸ | KDR | P35968 | 9/20 | 0.70 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.70 |
| ▸ | LCK | P06239 | 6/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.70 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398672 | 0.93 | MAPK14 (0.72) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL1406121 | 0.91 | MAPK14 (0.70) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL394468 | 0.91 | MAPK14 (0.67) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL397374 | 0.91 | MAPK14 (0.67) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396414 | 0.91 | MAPK14 (0.67) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL16576385 | 0.87 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2944446 | 0.86 | MAPK14 (0.75) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396187 | 0.86 | MAPK14 (0.69) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2955908 | 0.86 | MAPK14 (0.69) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL1406156 | 0.86 | MAPK14 (0.52) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |