Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14060283 | 0.87 | LRRK2 (0.69) | LRRK2 | |
| SCHEMBL14059777 | 0.84 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL14059522 | 0.84 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL17135952 | 0.82 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL17135955 | 0.82 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL14059649 | 0.81 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL14059953 | 0.79 | LRRK2 (0.62) | LRRK2 | |
| SCHEMBL14059393 | 0.79 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL14062326 | 0.78 | LRRK2 (0.69) | LRRK2 | |
| SCHEMBL14059382 | 0.78 | LRRK2 (0.68) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |