Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.68 |
| ▸ | KIT | P10721 | 10/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 11/20 | 0.62 |
| ▸ | LCK | P06239 | 8/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406063 | 0.90 | MAPK14 (0.56) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL396198 | 0.85 | MAPK14 (0.50) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL397267 | 0.84 | MAPK14 (0.53) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL395497 | 0.84 | MAPK14 (0.49) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL1406087 | 0.83 | MAPK14 (0.73) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL2953214 | 0.81 | MAPK14 (1.00) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL2948437 | 0.81 | MAPK14 (0.70) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL395416 | 0.80 | MAPK14 (0.75) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL395839 | 0.80 | MAPK14 (0.75) | MAPK14KITMAPK9MAPK10KDR | |
| SCHEMBL2955819 | 0.78 | MAPK14 (0.82) | MAPK14KITMAPK9MAPK10KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |