Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.75 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059230 | 0.91 | LRRK2 (0.71) | LRRK2CSF1R | |
| SCHEMBL14060049 | 0.86 | LRRK2 (0.73) | LRRK2CSF1R | |
| SCHEMBL14059908 | 0.86 | LRRK2 (1.00) | LRRK2CSF1R | |
| SCHEMBL14059972 | 0.84 | LRRK2 (1.00) | LRRK2CSF1R | |
| SCHEMBL14059531 | 0.81 | LRRK2 (0.75) | LRRK2CSF1R | |
| SCHEMBL14059204 | 0.79 | LRRK2 (0.46) | LRRK2ROCK2GSK3BCLK4 | |
| SCHEMBL14059953 | 0.78 | LRRK2 (0.62) | LRRK2CSF1R | |
| SCHEMBL17135863 | 0.77 | LRRK2 (1.00) | LRRK2CSF1R | |
| SCHEMBL14059621 | 0.77 | LRRK2 (1.00) | LRRK2CSF1R | |
| SCHEMBL14059619 | 0.77 | LRRK2 (1.00) | LRRK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |