SCHEMBL140598

SCHEMBL140598

COC(=O)c1cc(Cl)cc(Cl)c1N

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 13/20 0.61
GAA P10253 12/20 0.61
ALDH1A1 P00352 12/20 0.61
GLA P06280 9/20 0.61
HPGD P15428 9/20 0.59
MAPT P10636 3/20 0.59
HSD17B10 Q99714 2/20 0.59
NPSR1 Q6W5P4 1/20 0.56
ABL1 P00519 1/20 0.54
POLB P06746 3/20 0.54
ESR2 Q92731 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.52
NQO2 P16083 1/20 0.50
MEN1 O00255 1/20 0.45
PKM P14618 1/20 0.45
KMT2A Q03164 1/20 0.45
CTDSP1 Q9GZU7 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SERPINH1 P50454 1/20 0.45
SLC6A4 P31645 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL505256 0.85 ABL1 (0.64) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL6119775 0.84 GAA (0.50) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL1056378 0.84 ABL1 (0.53) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL1003428 0.84 ABL1 (0.53) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL24792656 0.82 GAA (0.49) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL28892465 0.82 ABL1 (0.51) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL1515035 0.82 KDM4E (0.58) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL29940209 0.82 ABL1 (0.51) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL3574538 0.82 GAA (0.49) KDM4EGAAALDH1A1GLAHPGD
SCHEMBL1059617 0.82 ABL1 (0.51) KDM4EGAAALDH1A1GLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117466762-A Preparation method of 2-amino-3, 5-dichloro-N-methylbenzamide 沈阳中化农药化工研发有限公司 2024-01-30 CN claimed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
CN-118184526-A Preparation method of 2-amino-3-chlorobenzoic acid methyl ester 鹤壁市宝瑞德化工有限公司 2024-06-14 CN disclosed
CN-115181031-B Preparation method of 2-amino-5-chlorobenzoic acid derivative 江苏扬农化工股份有限公司 2024-03-15 CN disclosed
CN-117466762-A Preparation method of 2-amino-3, 5-dichloro-N-methylbenzamide 沈阳中化农药化工研发有限公司 2024-01-30 CN disclosed
CN-117466762-A Preparation method of 2-amino-3, 5-dichloro-N-methylbenzamide 沈阳中化农药化工研发有限公司 2024-01-30 CN disclosed
CN-116730977-A Novel aryl heterocyclic compound, and preparation method and application thereof 华东理工大学 2023-09-12 CN disclosed
CN-115181031-A Preparation method of 2-amino-5-chlorobenzoic acid derivative 江苏扬农化工股份有限公司 2022-10-14 CN disclosed
CN-110305045-A A kind of amides compound and its purposes in treating cancer 成都海创药业有限公司 2019-10-08 CN disclosed
WO-2019179436-A1 ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS 成都海创药业有限公司 2019-09-26 WO disclosed
EP-2754651-B1 NITROBENZENE COMPOUND MANUFACTURING METHOD KUMIAI CHEMICAL INDUSTRY CO (JP) 2017-12-06 EP disclosed
US-4310677-A Preparation of alkyl anthranilates BASF AKTIENGESELLSCHAFT (DE) 1982-01-12 US disclosed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US disclosed
EP-0032672-A2 Process for the preparation of alkylesters of anthranilic acid BASF Aktiengesellschaft (DE) 1981-07-29 EP disclosed
US-4260540-A SPIN DYEING POLYACRYLONITRILE BAYER AKTIENGESELLSCHAFT (DE) 1981-04-07 US disclosed
US-4246401-A Axomethine pigments BAYER AKTIENGESELLSCHAFT (DE) 1981-01-20 US disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4094636-A DIAZOTIZATION HOECHST AKTIENGESELLSCHAFT (DT) 1978-06-13 US disclosed
US-4014863-A LACQUERS, PRINTING INKS, PAINTS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed
US-3953420-A Azo pigments derived from 2-hydroxy-3-carboxynaphthalene containing a substituted or unsubstituted phthalimide BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-04-27 US disclosed