Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059617 | 0.92 | LRRK2 (0.82) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059953 | 0.86 | LRRK2 (0.62) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059382 | 0.85 | LRRK2 (0.68) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059961 | 0.85 | LRRK2 (0.70) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059977 | 0.83 | LRRK2 (0.54) | LRRK2PDGFRA | |
| SCHEMBL14059133 | 0.83 | LRRK2 (0.55) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059804 | 0.82 | LRRK2 (1.00) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059623 | 0.82 | LRRK2 (0.58) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059531 | 0.82 | LRRK2 (0.75) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059208 | 0.82 | LRRK2 (0.61) | LRRK2PDGFRACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |