Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.53 |
| ▸ | KIT | P10721 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.53 |
| ▸ | LCK | P06239 | 6/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 7/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395774 | 0.93 | MAPK14 (0.51) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL395778 | 0.90 | MAPK14 (0.55) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952639 | 0.84 | MAPK14 (0.52) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396172 | 0.84 | MAPK14 (0.51) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954651 | 0.83 | MAPK14 (0.51) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL1406020 | 0.81 | MAPK14 (0.58) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2953857 | 0.81 | MAPK14 (0.48) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3953977 | 0.81 | MAPK14 (0.51) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396559 | 0.81 | MAPK14 (0.51) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2944146 | 0.80 | MAPK14 (0.54) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |