Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.57 |
| ▸ | GSK3A | P49840 | 3/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 9/20 | 0.47 |
| ▸ | MERTK | Q12866 | 9/20 | 0.47 |
| ▸ | FLT3 | P36888 | 8/20 | 0.47 |
| ▸ | GAS6 | Q14393 | 7/20 | 0.47 |
| ▸ | TYK2 | P29597 | 5/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.43 |
| ▸ | PLK1 | P53350 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14060018 | 1.00 | GSK3B (0.57) | GSK3BGSK3ATYRO3MERTKFLT3 | |
| SCHEMBL15795562 | 0.91 | AXL (0.46) | GSK3BGSK3ATYRO3MERTKFLT3 | |
| SCHEMBL14062224 | 0.86 | GSK3A (0.42) | GSK3BGSK3AFLT3TYK2AXL | |
| SCHEMBL14060866 | 0.86 | GSK3B (0.42) | GSK3BGSK3AFLT3TYK2AXL | |
| SCHEMBL14060868 | 0.86 | GSK3B (0.42) | GSK3BGSK3AFLT3TYK2AXL | |
| SCHEMBL14060800 | 0.85 | TYK2 (0.46) | GSK3BGSK3AMERTKFLT3TYK2 | |
| SCHEMBL14060893 | 0.85 | TYK2 (0.46) | GSK3BGSK3AMERTKFLT3TYK2 | |
| SCHEMBL14062109 | 0.85 | TYK2 (0.46) | GSK3BGSK3AMERTKFLT3TYK2 | |
| SCHEMBL14062111 | 0.85 | TYK2 (0.46) | GSK3BGSK3AMERTKFLT3TYK2 | |
| SCHEMBL15795064 | 0.84 | PLK1 (0.41) | GSK3BGSK3AFLT3TYK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140170110-A1 | PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES | ALMIRALL, S.A. (ES) | 2014-06-19 | — | — | US | disclosed |
| WO-2012160030-A1 | PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES | ALMIRALL, S.A. (ES) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140170110-A1 | PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES | JAK1, JAK3, JAK2 | GSK3B 827/4885GSK3A 954/4885TYRO3 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.