Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.52 |
| ▸ | KIT | P10721 | 10/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | LCK | P06239 | 7/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952103 | 0.86 | MAPK14 (0.55) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2957471 | 0.86 | MAPK14 (0.57) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2950842 | 0.85 | MAPK14 (0.53) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2946751 | 0.85 | MAPK14 (0.55) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2954302 | 0.84 | MAPK14 (0.54) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2953486 | 0.83 | MAPK14 (0.53) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL1406122 | 0.83 | MAPK14 (0.51) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2955016 | 0.82 | MAPK14 (0.73) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL1406043 | 0.82 | ABL1 (0.60) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL397085 | 0.82 | MAPK14 (0.49) | MAPK14KITKDRLCKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |