Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.77 |
| ▸ | KIT | P10721 | 10/20 | 0.77 |
| ▸ | KDR | P35968 | 9/20 | 0.77 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.77 |
| ▸ | LCK | P06239 | 6/20 | 0.77 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.77 |
| ▸ | LYN | P07948 | 1/20 | 0.77 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406009 | 1.00 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396376 | 0.91 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL393973 | 0.91 | MAPK14 (0.73) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL397312 | 0.90 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL398050 | 0.90 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL397175 | 0.90 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL398172 | 0.90 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL397124 | 0.88 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL395871 | 0.88 | MAPK14 (1.00) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL395967 | 0.88 | MAPK14 (1.00) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2011-03-09 | — | — | EP | disclosed |