Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 20/20 | 0.82 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065257 | 0.93 | LIMK2 (0.89) | LIMK2 | |
| SCHEMBL14065259 | 0.91 | LIMK2 (0.83) | LIMK2ROCK2LIMK1ROCK1 | |
| SCHEMBL14065263 | 0.91 | LIMK2 (0.86) | LIMK2 | |
| SCHEMBL14065280 | 0.90 | LIMK2 (0.90) | LIMK2 | |
| SCHEMBL14065261 | 0.90 | LIMK2 (1.00) | LIMK2 | |
| SCHEMBL14065262 | 0.90 | LIMK2 (0.89) | LIMK2 | |
| SCHEMBL14065264 | 0.90 | LIMK2 (0.89) | LIMK2 | |
| SCHEMBL14065321 | 0.89 | LIMK2 (0.88) | LIMK2 | |
| SCHEMBL14065301 | 0.89 | LIMK2 (0.93) | LIMK2 | |
| SCHEMBL14065260 | 0.88 | LIMK2 (0.83) | LIMK2ROCK2LIMK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |