Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 17/20 | 0.80 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.55 |
| ▸ | PRKACG | P22612 | 2/20 | 0.55 |
| ▸ | PRKACB | P22694 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065303 | 0.94 | LIMK2 (0.73) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065300 | 0.93 | LIMK2 (0.74) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065293 | 0.92 | LIMK2 (0.81) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065305 | 0.91 | LIMK2 (0.70) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065304 | 0.91 | LIMK2 (0.70) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065306 | 0.91 | LIMK2 (0.72) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065296 | 0.91 | LIMK2 (0.81) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065288 | 0.90 | LIMK2 (0.72) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065292 | 0.89 | LIMK2 (0.71) | LIMK2LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL14065308 | 0.88 | LIMK2 (0.67) | LIMK2LIMK1ROCK2PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |