Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 5/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866916 | 0.84 | LIMK2 (0.50) | F10 | |
| SCHEMBL4866804 | 0.84 | LIMK2 (0.62) | — | |
| Hydrochloric Acid SCHEMBL4866858 | 0.84 | LIMK2 (0.49) | F10 | |
| SCHEMBL14065267 | 0.83 | LIMK2 (0.63) | BTKKITF10 | |
| SCHEMBL14065316 | 0.82 | LRRK2 (0.49) | F10 | |
| SCHEMBL14073937 | 0.81 | F10 (0.47) | BTKKITF10 | |
| SCHEMBL14065312 | 0.79 | LIMK2 (0.48) | BTKF10 | |
| SCHEMBL14065315 | 0.79 | LIMK2 (0.60) | F10 | |
| SCHEMBL14065276 | 0.77 | LIMK2 (0.59) | BTKKITJAK3JAK2 | |
| SCHEMBL4302014 | 0.77 | LIMK2 (0.59) | AKT2BTKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |