Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15790744 | 0.82 | MAPT (0.35) | MAPTTDP1CYP2C9MEN1GAA | |
| SCHEMBL3252848 | 0.82 | MAPT (0.35) | MAPTTDP1CYP2C9MEN1GAA | |
| SCHEMBL365556 | 0.81 | MAPT (0.40) | MAPTTDP1CYP2C9MEN1GAA | |
| SCHEMBL1406151 | 0.81 | MAPT (0.35) | MAPTTDP1MEN1GAAKMT2A | |
| SCHEMBL18936339 | 0.81 | MAPT (0.35) | MAPTTDP1MEN1GAAKMT2A | |
| SCHEMBL1406284 | 0.80 | CYP2C9 (0.51) | MAPTTDP1CYP2C9MEN1GAA | |
| SCHEMBL1406206 | 0.80 | — | — | |
| SCHEMBL18936276 | 0.78 | MAPT (0.33) | MAPTMEN1GAAKMT2AKDM4E | |
| SCHEMBL18936277 | 0.78 | MAPT (0.33) | MAPTMEN1GAAKMT2AKDM4E | |
| SCHEMBL15779334 | 0.77 | CYP2C9 (0.33) | MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458670-B1 | METHOD FOR PRODUCING 2-HALOGENACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | SALTIGO GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1458670-A1 | METHOD FOR PRODUCING 2-HALOGENACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | Bayer Chemicals AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6706911-B1 | REACTING N-SUBSTITUTED 3-AMINOACRYLIC ESTERS WITH HALOALKYLCARBOXYLIC ANHYDRIDES IN PRESENCE OF BASE; PYRAZOLE-4-CARBOXYLIC ACID CHEMICAL INTERMEDIATES; HALOACYLATION | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-16 | — | — | US | disclosed |
| WO-2003051820-A1 | METHOD FOR PRODUCING 2-HALOGENACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | BAYER CHEMICALS AG (DE) | 2003-06-26 | — | — | WO | disclosed |