Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336570 | 0.89 | FGFR1 (0.58) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL2344062 | 0.87 | FGFR1 (0.62) | TP53TDP1HPGDKMT2ANPC1 | |
| SCHEMBL16082504 | 0.79 | TP53 (0.75) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL16082479 | 0.77 | TP53 (0.73) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL16082490 | 0.77 | TP53 (0.76) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL16082500 | 0.76 | TP53 (0.66) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL16082511 | 0.75 | TP53 (0.70) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL16082503 | 0.75 | TP53 (0.67) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL6664702 | 0.75 | TP53 (0.54) | TP53TDP1HPGDKMT2AMEN1 | |
| SCHEMBL19465045 | 0.74 | TP53 (0.69) | TP53TDP1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419995-B2 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419995-B2 | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library | OSI PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |