Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628717 | 0.88 | SGK1 (0.73) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL13628696 | 0.86 | SGK1 (0.71) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL13628711 | 0.85 | SGK1 (0.69) | SGK1LMNAMEN1KMT2AMAPT | |
| SCHEMBL13628704 | 0.85 | SGK1 (0.69) | SGK1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL13628719 | 0.84 | SGK1 (0.69) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL13628721 | 0.84 | SGK1 (0.69) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL14066128 | 0.84 | SGK1 (1.00) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL13628720 | 0.84 | SGK1 (0.65) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL13628771 | 0.83 | SGK1 (0.67) | SGK1LMNAMEN1KMT2APOLB | |
| SCHEMBL14066173 | 0.82 | SGK1 (0.80) | SGK1LMNAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214674-A1 | ACYLHYDRAZONE DERIVATIVES AND THE USE THEREOF IN THE INHIBITION, REGULATION AND/OR MODULATION OF KINASE SIGNAL TRANSDUCTION | GERICKE ROLF | 2008-09-04 | — | — | US | disclosed |
| US-20080214674-A1 | ACYLHYDRAZONE DERIVATIVES AND THE USE THEREOF IN THE INHIBITION, REGULATION AND/OR MODULATION OF KINASE SIGNAL TRANSDUCTION | GERICKE ROLF | 2008-09-04 | — | — | US | disclosed |
| US-7405239-B2 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction | MERCK PATENT GMBH (DE) | 2008-07-29 | — | — | US | disclosed |
| US-7405239-B2 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction | MERCK PATENT GMBH (DE) | 2008-07-29 | — | — | US | disclosed |
| US-20070060646-A1 | e.g. N-(4-hydroxy-2-methoxybenzylidene)-(3-hydroxyphenyl)acetohydrazide; human serum and glucocorticoid dependent kinase (SGK) inhibitor; antidiabetic, hypoglycemic agent, obesity; antiinflammatory, antiviral, neuroleptic agent | MERCK PATENT GMBH (DE) | 2007-03-15 | — | — | US | disclosed |
| US-20070060646-A1 | e.g. N-(4-hydroxy-2-methoxybenzylidene)-(3-hydroxyphenyl)acetohydrazide; human serum and glucocorticoid dependent kinase (SGK) inhibitor; antidiabetic, hypoglycemic agent, obesity; antiinflammatory, antiviral, neuroleptic agent | MERCK PATENT GMBH (DE) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214674-A1 | ACYLHYDRAZONE DERIVATIVES AND THE USE THEREOF IN THE INHIBITION, REGULATION AND/OR MODULATION OF KINASE SIGNAL TRANSDUCTION | SGK3, OXSR1, GRK3 | SGK1 8/4885LMNA 4254/4885MEN1 4722/4885 |
| US-20070060646-A1 | e.g. N-(4-hydroxy-2-methoxybenzylidene)-(3-hydroxyphenyl)acetohydrazide; human serum and glucocorticoid dependent kinase (SGK) inhibitor; antidiabetic, hypoglycemic agent, obesity; antiinflammatory, antiviral, neuroleptic agent | SGK3, GRK3, GRK4 | SGK1 4/4885LMNA 3815/4885MEN1 4524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.