Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 10/20 | 0.58 |
| ▸ | PI4K2B | Q8TCG2 | 10/20 | 0.58 |
| ▸ | PI4K2A | Q9BTU6 | 10/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25882848 | 0.84 | PI4KA (0.55) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL29010473 | 0.83 | PI4KB (0.54) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL25883349 | 0.83 | PI4KB (0.54) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL14066381 | 0.81 | MAP4K4 (0.41) | PTK2PTK2BMAP4K4MAPKAPK2 | |
| SCHEMBL14191791 | 0.76 | PTK2 (0.60) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL13499151 | 0.76 | MAP4K4 (0.44) | MAP4K4MAPKAPK2 | |
| SCHEMBL4875436 | 0.76 | PTK2 (0.62) | PTK2PTK2B | |
| SCHEMBL29010471 | 0.75 | PI4KA (0.55) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| Hydrochloric Acid SCHEMBL5111052 | 0.75 | PTK2 (0.59) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL5113125 | 0.75 | PI4KA (0.44) | PI4KAPI4K2BPI4K2API4KBPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | TIE1, FLT1, RET | PI4KA 457/4885PI4K2B 620/4885PI4K2A 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.