Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26527407 | 0.85 | NOTUM (0.39) | NOTUMHSP90AA1HSP90AB1EPHX2CHEK1 | |
| SCHEMBL1090646 | 0.82 | NOTUM (0.44) | NOTUMEPHX2SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5788169 | 0.81 | NOTUM (0.41) | NOTUMHSP90AA1HSP90AB1CHEK1AURKA | |
| SCHEMBL5788632 | 0.77 | EPHX2 (0.35) | NOTUMEPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL20661453 | 0.77 | SLC6A4 (0.32) | DAPK3JAK2PRKD3MAP4K4RET | |
| SCHEMBL8302237 | 0.76 | TSHR (0.36) | RXRASMN1; SMN2TSHRUSP2ALDH1A1 | |
| SCHEMBL16477942 | 0.74 | VHL (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL15354785 | 0.74 | VHL (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL25095286 | 0.74 | NOTUM (0.48) | NOTUMCHEK1AURKADAPK3JAK2 | |
| SCHEMBL5791938 | 0.73 | NOTUM (0.33) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704143-B1 | MALONONITRILE COMPOUND AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2008-09-03 | — | — | EP | disclosed |