Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437158 | 0.90 | MAPT (0.44) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL4432077 | 0.84 | MAPT (0.46) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL4443596 | 0.76 | MAPT (0.44) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL9425659 | 0.76 | MAPT (0.67) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL1710516 | 0.75 | MAPT (0.65) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL4563218 | 0.74 | MAPT (0.40) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL16702811 | 0.73 | LATS1 (0.49) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL31302472 | 0.73 | MAPT (0.39) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL16505318 | 0.71 | MAPT (0.50) | MAPTHTTPOLBALDH1A1MAPK1 | |
| SCHEMBL16505317 | 0.71 | MAPT (0.50) | MAPTHTTPOLBALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-B1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |