Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.42 |
| ▸ | PIM1 | P11309 | 7/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11906686 | 0.92 | PIM2 (0.50) | MAP4K4PIM3PIM2PIM1GSK3B | |
| SCHEMBL4565716 | 0.92 | PIM2 (0.50) | MAP4K4PIM3PIM2PIM1GSK3B | |
| SCHEMBL4565715 | 0.84 | MAP4K4 (0.43) | MAP4K4PIM3PIM2PIM1BTK | |
| SCHEMBL14068070 | 0.84 | PIM2 (0.38) | PIM3PIM2PIM1GSK3BDYRK1A | |
| SCHEMBL14067915 | 0.84 | PIM2 (0.38) | PIM3PIM2PIM1GSK3BDYRK1A | |
| SCHEMBL11907983 | 0.82 | PIM2 (0.48) | PIM3PIM2PIM1BTK | |
| SCHEMBL11907982 | 0.82 | PIM2 (0.48) | PIM3PIM2PIM1BTK | |
| SCHEMBL4442443 | 0.80 | PIM2 (0.45) | MAP4K4PIM3PIM2PIM1BTK | |
| SCHEMBL4442444 | 0.80 | PIM2 (0.45) | MAP4K4PIM3PIM2PIM1BTK | |
| SCHEMBL11907439 | 0.80 | PIM2 (0.55) | MAP4K4PIM3PIM2PIM1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |