Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857744 | 0.89 | ATM (0.53) | ATMACECYP3A4APPCTSS | |
| SCHEMBL14030166 | 0.89 | ATM (0.53) | ATMACECYP3A4APPCTSS | |
| SCHEMBL6857746 | 0.89 | ATM (0.53) | ATMACECYP3A4APPCTSS | |
| SCHEMBL14004830 | 0.89 | ATM (0.53) | ATMACECYP3A4APPCTSS | |
| SCHEMBL14068584 | 0.88 | ATM (0.39) | ATMACECYP3A4JAK2ALDH1A1 | |
| SCHEMBL6854766 | 0.87 | ATM (0.51) | ATMACECYP3A4APPCTSS | |
| SCHEMBL6854769 | 0.87 | ATM (0.51) | ATMACECYP3A4APPCTSS | |
| SCHEMBL30639552 | 0.84 | ATM (0.65) | ATMACECYP3A4APPCTSS | |
| SCHEMBL7596617 | 0.81 | ATM (0.51) | ATMACECYP3A4APP | |
| SCHEMBL14441492 | 0.81 | ATM (0.51) | ATMACECYP3A4APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |