Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406506 | 0.94 | EGFR (0.79) | EGFRERBB2KCNH2 | |
| SCHEMBL1406983 | 0.87 | ERBB2 (0.86) | EGFRERBB2 | |
| SCHEMBL2522758 | 0.85 | EGFR (0.67) | EGFRERBB2KCNH2 | |
| SCHEMBL1406607 | 0.84 | EGFR (0.77) | EGFRERBB2KCNH2 | |
| SCHEMBL1406409 | 0.84 | ERBB2 (0.80) | EGFRERBB2KCNH2 | |
| SCHEMBL1406939 | 0.83 | EGFR (1.00) | EGFRERBB2KCNH2 | |
| SCHEMBL1406470 | 0.81 | ERBB2 (1.00) | EGFRERBB2KCNH2 | |
| SCHEMBL1406498 | 0.81 | EGFR (0.94) | EGFRERBB2KCNH2 | |
| SCHEMBL1406420 | 0.80 | ERBB2 (1.00) | EGFRERBB2 | |
| SCHEMBL1406572 | 0.80 | ERBB2 (0.77) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838712-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |