Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 11/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14070260 | 0.94 | BTK (0.47) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14069748 | 0.91 | BTK (0.47) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14070219 | 0.91 | BTK (0.56) | BTKBRAFLCKINSRLYN | |
| SCHEMBL14069747 | 0.89 | BTK (0.45) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14070266 | 0.89 | BTK (0.47) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14069750 | 0.88 | BTK (0.53) | BTKBRAFLCKINSRLYN | |
| SCHEMBL14070189 | 0.87 | BTK (0.65) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14070292 | 0.87 | BRAF (0.48) | BTKMAPK14BRAFLCKINSR | |
| SCHEMBL14070270 | 0.87 | KDM4E (0.46) | BTKBRAFLCKINSRLYN | |
| SCHEMBL14070291 | 0.87 | BTK (0.44) | BTKMAPK14BRAFLCKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |