Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.58 |
| ▸ | BRAF | P15056 | 10/20 | 0.56 |
| ▸ | LCK | P06239 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | INSR | P06213 | 4/20 | 0.56 |
| ▸ | LYN | P07948 | 4/20 | 0.56 |
| ▸ | HCK | P08631 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 4/20 | 0.56 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.56 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.56 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.56 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.56 |
| ▸ | AGPS | O00116 | 2/20 | 0.56 |
| ▸ | MYO1F | O00160 | 2/20 | 0.56 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.56 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.56 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.56 |
| ▸ | PGRMC1 | O00264 | 2/20 | 0.56 |
| ▸ | CLIC1 | O00299 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069863 | 0.98 | BTK (0.58) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070282 | 0.96 | BTK (0.60) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070189 | 0.92 | BTK (0.65) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070248 | 0.92 | BTK (0.60) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070275 | 0.91 | BTK (0.59) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14069836 | 0.90 | BTK (0.67) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070271 | 0.90 | BTK (0.61) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070277 | 0.89 | BTK (0.60) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14069856 | 0.89 | LCK (0.66) | BTKBRAFLCKKDRINSR | |
| SCHEMBL14070219 | 0.87 | BTK (0.56) | BTKBRAFLCKKDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |