Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 10/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14342822 | 1.00 | NR1I2 (0.67) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13846669 | 0.94 | NR1I2 (0.60) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13841553 | 0.92 | KCNH2 (0.57) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL14095053 | 0.91 | NR1I2 (0.68) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL14026076 | 0.90 | NR1I2 (0.67) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL14095546 | 0.90 | NR1I2 (0.62) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL16711671 | 0.90 | NR1I2 (0.81) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL18051484 | 0.90 | NR1I2 (0.56) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL10155794 | 0.89 | KCNH2 (0.55) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL14343917 | 0.89 | NR1I2 (0.64) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118109-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2008112473-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-18 | — | — | WO | disclosed |