Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332699 | 0.92 | PPARG (0.38) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL333611 | 0.91 | PPARG (0.47) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL333879 | 0.90 | PPARG (0.41) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL10076916 | 0.89 | PPARG (0.47) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL332700 | 0.89 | MEN1 (0.41) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL333845 | 0.89 | PPARG (0.42) | PPARGPPARAUSP14KDM4EHIF1A | |
| SCHEMBL333656 | 0.88 | PPARG (0.43) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL333774 | 0.87 | PPARG (0.46) | PPARGPPARAMEN1KMT2APLA2G4A | |
| SCHEMBL332701 | 0.86 | MEN1 (0.38) | PPARGPPARAMEN1KMT2AUSP14 | |
| SCHEMBL334287 | 0.85 | FFAR1 (0.43) | PPARGMEN1KMT2AUSP14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841735-B1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2011-03-09 | — | — | EP | disclosed |