Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 4/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406770 | 0.92 | POLB (0.56) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1407048 | 0.91 | POLB (0.55) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1406914 | 0.91 | POLB (0.55) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1407088 | 0.88 | POLB (0.53) | POLBEPHX2CNR2CNR1ALDH1A1 | |
| SCHEMBL1407259 | 0.88 | POLB (0.53) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1406598 | 0.88 | POLB (0.53) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1407044 | 0.88 | POLB (0.50) | POLBKDM4ECNR2CNR1CASR | |
| SCHEMBL1406820 | 0.85 | POLB (0.50) | POLBEPHX2CNR2CNR1CASR | |
| SCHEMBL1406965 | 0.84 | POLB (0.51) | POLBEPHX2KDM4ECNR2CNR1 | |
| SCHEMBL1406815 | 0.84 | POLB (0.51) | POLBEPHX2KDM4ECNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-B1 | PYRAZOLES AS 11-BETA-HSD-1 | HOFFMANN LA ROCHE (CH) | 2015-07-22 | — | — | EP | disclosed |
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |