Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 19/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 19/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408073 | 0.93 | NR1H2 (0.57) | NR1H2NR1H3ALDH1A1 | |
| SCHEMBL1407334 | 0.90 | NR1H2 (0.62) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1407810 | 0.88 | NR1H2 (0.59) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27730719 | 0.86 | NR1H2 (0.56) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3861003 | 0.85 | NR1H2 (0.73) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1407670 | 0.85 | NR1H2 (0.62) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL27710192 | 0.84 | NR1H2 (0.58) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1407473 | 0.83 | NR1H2 (0.62) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1407897 | 0.83 | NR1H2 (0.61) | NR1H2NR1H3ALDH1A1 | |
| SCHEMBL1407779 | 0.82 | NR1H2 (0.63) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295429-A1 | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7592363-B2 | Indazoles | WYETH (US) | 2009-09-22 | — | — | US | disclosed |
| US-20060030612-A1 | Indazoles useful in treating cardiovascular diseases | WYETH (US) | 2006-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030612-A1 | Indazoles useful in treating cardiovascular diseases | NR1H2, NR1H3, CYP46A1 | NR1H2 1/4885NR1H3 2/4885PPARG 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.