Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341650 | 0.86 | BRAF (0.68) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4328870 | 0.86 | BRAF (0.58) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4325173 | 0.85 | BRAF (0.69) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4326139 | 0.85 | BRAF (0.69) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4333313 | 0.85 | BRAF (0.69) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4334932 | 0.84 | BRAF (0.75) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4336519 | 0.83 | BRAF (0.65) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4331290 | 0.83 | BRAF (0.62) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4331258 | 0.83 | BRAF (0.79) | BRAFLCKRAF1FYNPDGFRB | |
| SCHEMBL4327476 | 0.83 | BRAF (0.66) | BRAFLCKRAF1FYNPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423150-B2 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase | NOVARTIS AG (CH) | 2008-09-09 | — | — | US | disclosed |
| US-7423150-B2 | Substituted benzazoles and methods of their use as inhibitors of Raf kinase | NOVARTIS AG (CH) | 2008-09-09 | — | — | US | disclosed |