Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407085 | 0.93 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1415167 | 0.91 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407083 | 0.91 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407737 | 0.87 | NR1H2 (0.53) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407858 | 0.87 | NR1H2 (0.47) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1414616 | 0.85 | NR1H2 (0.56) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407419 | 0.80 | NR1H2 (0.63) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1414445 | 0.79 | NR1H2 (0.51) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27710174 | 0.78 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407772 | 0.78 | NR1H2 (0.46) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295429-A1 | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |