Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14077951 | 0.89 | BTK (0.69) | BTKSYKLCKTNKS | |
| SCHEMBL14077952 | 0.87 | BTK (0.58) | BTKSYKLCKJAK3TNKS | |
| SCHEMBL9068893 | 0.85 | BTK (0.59) | BTKSYKHPGDRXFP1TNKS | |
| SCHEMBL9005193 | 0.84 | BTK (0.71) | BTKLCKJAK3 | |
| SCHEMBL9004538 | 0.82 | BTK (0.84) | BTKLCKJAK3 | |
| SCHEMBL9004583 | 0.82 | BTK (0.84) | BTKLCKJAK3 | |
| SCHEMBL9004682 | 0.82 | BTK (0.58) | BTKHPGDRXFP1TNKS | |
| SCHEMBL14077950 | 0.81 | SYK (0.56) | BTKSYKLCKJAK3HPGD | |
| SCHEMBL9004734 | 0.81 | BTK (0.57) | BTKSYKHPGDRXFP1TNKS | |
| SCHEMBL9004540 | 0.80 | BTK (0.59) | BTKLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125819-B1 | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases | BRISTOL MYERS SQUIBB CO (US) | 2014-10-22 | — | — | EP | disclosed |
| WO-2008116064-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE, ALLERGIC, AUTOIMMUNE OR INFLAMMATORY DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-25 | — | — | WO | disclosed |