Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.57 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | PTPRB | P23467 | 2/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407640 | 0.92 | NR1H2 (0.55) | NR1H2NR1H3PTPN2PTPN1PTPRB | |
| SCHEMBL1406905 | 0.88 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3863717 | 0.86 | NR1H2 (0.77) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27710182 | 0.85 | NR1H2 (0.69) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407090 | 0.84 | NR1H2 (0.64) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407271 | 0.84 | NR1H2 (0.64) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407894 | 0.84 | NR1H2 (0.59) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3859782 | 0.83 | NR1H2 (0.72) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407160 | 0.82 | NR1H2 (0.61) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407677 | 0.81 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295429-A1 | 3-((hetero)aryl)-indazoles as Liver X receptor (LXR) and Th-1 inhibitors for the treatment of cardiovascular diseases | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |