Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.67 |
| ▸ | MEN1 | O00255 | 11/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14082221 | 0.90 | MAPT (0.66) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL12648540 | 0.89 | MAPT (0.67) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL12648526 | 0.87 | MAPT (0.66) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL14082218 | 0.81 | MEN1 (0.60) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL12648531 | 0.79 | CFTR (0.69) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL12872564 | 0.76 | MAPT (0.52) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL17080646 | 0.74 | KMT2A (0.69) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL14082172 | 0.72 | MAPT (0.53) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL14082217 | 0.72 | MEN1 (0.67) | MAPTMEN1KMT2AMCL1KDM4E | |
| SCHEMBL15521408 | 0.72 | MAPT (0.61) | MAPTMEN1KMT2AMCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414037-B2 | cystic fibrosis transmembrane conductance regulator protein inhibitor; 2-naphthalenylamino-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene][3-[4-(3-(PEG)n-thioureido)diphenyl)-thioureido]propanedioic acid dihydrazide (MalH-(PEG)nB); cystic fibrosis with forms of male infertility, secretory diarrhea | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-08-19 | — | — | US | disclosed |