Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | MTOR | P42345 | 20/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32266 | 0.88 | MTOR (0.74) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL32273 | 0.86 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1409088 | 0.85 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL1409229 | 0.83 | PIK3CA (0.64) | PIK3CAMTORPIK3CG | |
| SCHEMBL1409234 | 0.81 | PIK3CA (0.68) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL32307 | 0.80 | PIK3CA (0.72) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL32190 | 0.77 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL32420 | 0.76 | MTOR (0.91) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL32289 | 0.75 | PIK3CA (1.00) | PIK3CAMTORPIK3CG | |
| SCHEMBL32400 | 0.75 | MTOR (1.00) | PIK3CAMTORPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294072-A1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | Wyeth LLC (US) | 2011-03-16 | — | — | EP | disclosed |
| WO-2009143313-A1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | WYETH (US) | 2009-11-26 | — | — | WO | disclosed |