Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 15/20 | 0.46 |
| ▸ | CHUK | O15111 | 14/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392326 | 0.89 | MAPT (0.50) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL3303685 | 0.89 | MAPT (0.50) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL3300131 | 0.89 | MAPT (0.50) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL3302525 | 0.88 | MAPT (0.47) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL3299594 | 0.88 | MAPT (0.47) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL14095890 | 0.86 | IKBKB (0.46) | MAPTKMT2AIDH1IKBKBCHUK | |
| SCHEMBL3300355 | 0.85 | MAPT (0.47) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL3301684 | 0.85 | MAPT (0.47) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL13392132 | 0.85 | MAPT (0.54) | MAPTMEN1NPC1LMNAALOX12 | |
| SCHEMBL13392500 | 0.84 | MAPT (0.56) | MAPTMEN1NPC1LMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099073-A1 | N, N' -2, 4-DIANILINOPYRIMIDINES PREPARATION AND USE THEREOF AS IKK INHIBITORS PREPARATION AND TEH PHARMACUETICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |