Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14395390 | 0.81 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097686 | 0.79 | ABL1 (0.40) | ABL1 | |
| SCHEMBL14097692 | 0.78 | ABL1 (0.40) | ABL1 | |
| SCHEMBL14097698 | 0.77 | ABL1 (0.39) | ABL1 | |
| SCHEMBL14097687 | 0.74 | MAPK8 (0.41) | ABL1 | |
| SCHEMBL14097697 | 0.74 | PIK3CA (0.36) | ABL1 | |
| SCHEMBL14097711 | 0.73 | ABL1 (0.49) | ABL1GSK3B | |
| SCHEMBL14097701 | 0.72 | ABL1 (0.48) | ABL1GSK3BMAPTMEN1KMT2A | |
| SCHEMBL14097684 | 0.69 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097689 | 0.69 | ABL1 (0.37) | ABL1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |