Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 16/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081749 | 1.00 | ABL1 (0.57) | ABL1 | |
| SCHEMBL14097615 | 0.92 | ABL1 (0.49) | ABL1 | |
| SCHEMBL3851404 | 0.90 | ABL1 (0.53) | ABL1 | |
| SCHEMBL5081745 | 0.90 | ABL1 (0.47) | ABL1 | |
| SCHEMBL14097723 | 0.85 | ABL1 (0.48) | ABL1 | |
| SCHEMBL14097616 | 0.82 | ABL1 (0.48) | ABL1 | |
| SCHEMBL5081746 | 0.81 | ABL1 (0.44) | ABL1 | |
| SCHEMBL14097655 | 0.79 | ABL1 (0.43) | ABL1 | |
| SCHEMBL14097632 | 0.79 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097654 | 0.79 | KDM4E (0.44) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |