Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | ETV6 | P41212 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928117 | 0.87 | PLK4 (0.58) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL4222794 | 0.86 | LRRK2 (0.51) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL16025551 | 0.84 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL3710632 | 0.83 | TTK (0.52) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL29602504 | 0.83 | LRRK2 (0.68) | LRRK2KDRETV6MAPK1TDO2 | |
| SCHEMBL12795343 | 0.82 | PLK4 (0.51) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL12864090 | 0.77 | CNR2 (0.62) | CNR2 | |
| SCHEMBL6506307 | 0.76 | LRRK2 (0.53) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL31613742 | 0.76 | MAPK1 (0.50) | LRRK2PLK4FLT3KDRETV6 | |
| SCHEMBL14863607 | 0.76 | KDR (0.57) | LRRK2KDRETV6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708996-B1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |