Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.72 |
| ▸ | ESR1 | P03372 | 5/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8266789 | 0.94 | ESR1 (0.72) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL8176145 | 0.84 | ESR2 (1.00) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL4171874 | 0.82 | ESR2 (0.64) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL29963966 | 0.82 | ESR2 (0.72) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL4179872 | 0.82 | ESR2 (0.72) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL25206226 | 0.82 | ESR2 (0.76) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL3874010 | 0.82 | ESR2 (0.72) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL419896 | 0.82 | ESR2 (0.72) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL3895230 | 0.82 | ESR1 (1.00) | ESR2ESR1HDAC8HDAC6ABHD6 | |
| SCHEMBL14569347 | 0.82 | ESR2 (0.67) | ESR2ESR1HDAC8HDAC6ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
| EP-1501803-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | ESR2 3632/4885ESR1 4314/4885HDAC8 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.