Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Erteberel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 20/20 | 1.00 |
| ▸ | ESR1 | P03372 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Erteberel SCHEMBL14514704 | 1.00 | ESR2 (1.00) | ESR2ESR1 | |
| Erteberel SCHEMBL14534968 | 1.00 | ESR2 (1.00) | ESR2ESR1 | |
| Erteberel SCHEMBL14514726 | 1.00 | ESR2 (1.00) | ESR2ESR1 | |
| Erteberel SCHEMBL14102383 | 1.00 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL14047367 | 0.97 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL14514709 | 0.96 | ESR2 (1.00) | ESR2ESR1 | |
| SCHEMBL14514763 | 0.92 | ESR2 (0.85) | ESR2ESR1 | |
| SCHEMBL14514602 | 0.92 | ESR2 (0.85) | ESR2ESR1 | |
| SCHEMBL14514616 | 0.92 | ESR2 (0.85) | ESR2ESR1 | |
| SCHEMBL14514703 | 0.89 | ESR2 (0.81) | ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626974-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1790644-A1 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1448544-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2007-05-16 | — | — | EP | disclosed |
| US-7217734-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217734-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2007-05-15 | — | — | US | disclosed |