SCHEMBL1410253

SCHEMBL1410253

CC(C)C[C@@H](NCc1ccc(/C=C/C(=O)NO)cc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 13/20 0.56
HDAC8 Q9BY41 13/20 0.56
HDAC2 Q92769 12/20 0.56
HDAC1 Q13547 11/20 0.56
HDAC6 Q9UBN7 7/20 0.50
HDAC4 P56524 5/20 0.49
HDAC5 Q9UQL6 5/20 0.49
HDAC7 Q8WUI4 4/20 0.49
HDAC10 Q969S8 4/20 0.49
HDAC11 Q96DB2 4/20 0.49
HDAC9 Q9UKV0 4/20 0.49
NOS3 P29474 2/20 0.47
NOS1 P29475 2/20 0.47
NOS2 P35228 2/20 0.47
TAS1R3 Q7RTX0 1/20 0.47
TAS1R1 Q7RTX1 1/20 0.47
CTSK P43235 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1410908 1.00 HDAC3 (0.56) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1410257 1.00 HDAC3 (0.56) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1410913 1.00 HDAC3 (0.56) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1411147 0.96 HDAC1 (0.62) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1411149 0.96 HDAC1 (0.62) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1411152 0.96 HDAC1 (0.62) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL19712552 0.96 HDAC1 (0.62) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1410865 0.88 HDAC6 (0.51) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1410866 0.88 HDAC6 (0.51) HDAC3HDAC8HDAC2HDAC1HDAC6
SCHEMBL1410862 0.88 HDAC6 (0.51) HDAC3HDAC8HDAC2HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069291-B1 HDAC INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2017-12-20 EP disclosed
EP-2295410-A1 HDAC inhibitor Chroma Therapeutics Limited (GB) 2011-03-16 EP disclosed