Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410314 | 0.85 | NOTUM (0.50) | NOTUMPDE3BPDE3AHSD11B1IDH2 | |
| SCHEMBL1410608 | 0.84 | NOTUM (0.67) | NOTUMP2RX7PDE3BPDE3AHSD11B1 | |
| SCHEMBL18064830 | 0.80 | NOTUM (0.49) | NOTUMP2RX7PDE3BPDE3AHSD11B1 | |
| SCHEMBL16814894 | 0.80 | NOTUM (0.46) | NOTUMP2RX7PDE3BPDE3AHSD11B1 | |
| SCHEMBL18064789 | 0.80 | NOTUM (0.49) | NOTUMP2RX7PDE3BPDE3AHSD11B1 | |
| SCHEMBL2940182 | 0.79 | NOTUM (0.49) | NOTUMAR | |
| SCHEMBL1410334 | 0.77 | PDE3B (0.52) | NOTUMPDE3BPDE3AHSD11B1IDH2 | |
| SCHEMBL1410383 | 0.76 | NOTUM (0.49) | NOTUMP2RX7RORC | |
| SCHEMBL2517376 | 0.76 | NOTUM (0.48) | NOTUMP2RX7 | |
| SCHEMBL2940337 | 0.75 | IDH2 (0.42) | NOTUMPDE3BPDE3AHSD11B1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295406-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-8338622-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-25 | — | — | US | disclosed |
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-13 | — | — | US | disclosed |
| EP-2295406-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | NES, BMI1, DOT1L | NOTUM 874/4885P2RX7 802/4885PDE3B 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.